What is the root cause? It depends on the individual person. IBS is a multi-factorial disorder and it can have multiple root causes. They may include:
- Eating highly processed, low-fibre diet
- Low water intake
- Altered gut flora (dysbiosis): Dysbiosis happens when the bad bugs in your gut take over. People with imbalance of GI bacteria are more prone to symptoms of IBS (2). Dysbiosis is common due to overuse of antibiotics, as well as alcohol, high sugar diet and stress. Healthy gut flora contributes to production of amino acids, certain vitamins, as well as neurotransmitters, such as your happy hormone serotonin.
- Food sensitivities and intolerances: IBS sufferers often report sensitivity to certain foods, commonly to certain carbohydrates (especially foods containing gluten), as well as certain fats (3,4). Lactose intolerance is also a common cause of IBS and it can be diagnosed by simple breath test.
- Stress: Those under a lot of stress, as well people suffering from anxiety and depression are more prone to experience IBS symptoms (5). Our gut is also called a “second brain” and many IBS sufferers link their emotions and stress levels to worsening of the symptoms.
- SIBO – Small Intestinal Bacterial Overgrowth: a condition characterised by abnormal overgrowth of bacteria in the small intestine. It is estimated that up to 84% of IBS sufferers have SIBO (6). Most of the gut bacteria is meant to be located in the large intestine, where they help to break down food, synthesize vitamins, and eliminate waste. In SIBO these healthy bacteria colonise the small intestine. People with SIBO will have excess levels of hydrogen, methane or both, and it can be diagnosed by hydrogen and methane breath test (7).
- Increased intestinal permeability (“leaky gut syndrome”): Studies have also shown an association between IBS and increased intestinal permeability (8). The gut lining is like a net with extremely small holes to allow certain substances to pass through. In a leaky gut those holes become bigger allowing undigested food particles, proteins, toxins and bad bacteria to pass through. An unhealthy gut lining makes it harder for digestion to work at optimal level.
- Gut infections: Certain gut infections have been associated with IBS. For example intestinal parasites such as Blastocystis hominis and Dientamoeba fragilis, as well as food poisoning caused by Campylobacter bacteria may trigger IBS (9,10).
- Lack of exercise: Exercise is crucial for the functioning of your digestive system. If you are inactive, so will be your digestion. On the other hand, if you are active, your digestion will follow.
References
(1) Agrawal, Whorwell. Irritable bowel syndrome: diagnosis and management. BMJ. 2006; 332: 280-83.
(2) Kassinen A, Krogius-Kurikka L, Mäkivuokko H, et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 2007;133(1):24.
(3) Simrén M, Månsson A, Langkilde AM, et al. Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion. 2001;63(2):108.
(4) Pasquale Mansueto, Alberto D’Alcamo, Aurelio Seidita, et al. Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity. World J Gastroenterol. 2015 Jun 21; 21(23): 7089–7109.
(5) Nicholl BI, Halder SL, Macfarlane GJ, et al. Psychosocial risk markers for new onset irritable bowel syndrome–results of a large prospective population-based study. Pain. 2008;137(1):147.
(6) Pimentel M1, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol. 2000 Dec;95(12):3503-6.
(7) Jan Bures, Jiri Cyrany, Darina Kohoutova et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28; 16(24): 2978–2990.
(8) Camilleri M1, Madsen K, Spiller R, Greenwood-Van Meerveld B et. al., Intestinal barrier function in health and gastrointestinal disease. Neurogastroenterol Motil. 2012 Jun;24(6):503-12. doi: 10.1111/j.1365-2982.2012.01921.x.
(9) Stark D1, van Hal S, Marriott D, Ellis J et al., Irritable bowel syndrome: a review on the role of intestinal protozoa and the importance of their detection and diagnosis. Int J Parasitol. 2007 Jan;37(1):11-20. Epub 2006 Oct 12.
(10) Swan C1, Duroudier NP, Campbell E et al., Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut. 2013 Jul;62(7):985-94. doi: 10.1136/gutjnl-2011-301213. Epub 2012 Jun